Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

10.1K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
10.1K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

16.0K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
16.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Contrasting phagocyte respiratory burst responses in two European bat species during hibernation.

Frontiers in immunology·2026
Same author

The effect of <i>Lactiplantibacillus plantarum</i> probiotic supplement on rainbow trout challenged with <i>Aeromonas salmonicida</i>.

Veterinarni medicina·2026
Same author

Seasonal Turnover in Bat Skin Mycobiota: Contrasting Fungal Communities Between Hibernation and Reproduction in Greater Mouse-Eared Bats (<i>Myotis myotis</i>).

Pathogens (Basel, Switzerland)·2026
Same author

Bat species tolerant and susceptible to fungal infection show transcriptomic differences in late hibernation and healing.

The Journal of experimental biology·2025
Same author

Functional Screen of Wilson Disease ATP7B Variants Reveals Residual Transport Activities.

Human mutation·2025
Same author

Ecological speciation with gene flow followed initial large-scale geographic speciation in the enigmatic afroalpine giant senecios (Dendrosenecio).

The New phytologist·2025

相关实验视频

Updated: Feb 28, 2026

Tissue Collection of Bats for -Omics Analyses and Primary Cell Culture
15:31

Tissue Collection of Bats for -Omics Analyses and Primary Cell Culture

Published on: October 23, 2019

13.0K

全基因组协会揭示了冬眠蝙蝠的信号链接感染耐受性.

Markéta Harazim1,2, Lubomír Piálek1,3, Hana Bandouchova4

  • 1Institute of Vertebrate Biology, Czech Academy of Sciences, Květná 8, 60300 Brno, Czech Republic.

Pathogens (Basel, Switzerland)
|February 27, 2026
PubMed
概括

蝙蝠的基因组变异会影响它们在冬眠期间的健康状况,影响它们对感染的易感性. 由于这些遗传因素,蝙蝠在冬眠时可能会优先考虑感染耐受性而不是耐药性.

关键词:
长腿动物 (Chiroptera) 是一个类动物.适应 适应 适应 适应全基因组关联研究研究.感染感染的感染.白鼻子综合征是什么意思

更多相关视频

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
08:32

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Published on: March 2, 2014

11.0K
Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous &#946;2-Microglobulin
11:17

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin

Published on: March 10, 2021

6.8K

相关实验视频

Last Updated: Feb 28, 2026

Tissue Collection of Bats for -Omics Analyses and Primary Cell Culture
15:31

Tissue Collection of Bats for -Omics Analyses and Primary Cell Culture

Published on: October 23, 2019

13.0K
Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
08:32

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Published on: March 2, 2014

11.0K
Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous &#946;2-Microglobulin
11:17

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin

Published on: March 10, 2021

6.8K

科学领域:

  • 基因组学就是基因组学.
  • 免疫学 免疫学 免疫学
  • 兽医科学 兽医科学 兽医科学

背景情况:

  • 冬眠通过抑制新陈代谢和免疫功能来改变宿主-病原体的动态.
  • 这给冬眠动物控制感染带来了挑战.

研究的目的:

  • 研究基因组变异如何影响冬眠蝙蝠的感染易感性和生理特征.
  • 在冬眠期间识别特定的基因和与健康特征相关的遗传变异.

主要方法:

  • 在五种温带蝙蝠物种上进行了全基因组测序.
  • 进行了感染查,血液学和血液生物化学.
  • 基因信息树WAS框架被用来将单核酸变异 (SNV) 与健康变量关联起来.

主要成果:

  • 确定了超过17万种SNV,其中515种与感染和生理特征有显著联系.
  • 相关的SNV映射到137个基因中,丰富了细胞骨动力学,膜贩运和细胞内信号传输.
  • 规范性免疫基因的代表性不足,这表明调节位置是关键的.

结论:

  • 蝙蝠基因组变异在能量有限的冬眠状态下塑造了对感染的生理反应.
  • 这些发现支持了蝙蝠在冬眠期间利用感染耐受性而不是耐药性的假设.
  • 调节和信号通路对于保持冬眠者健康至关重要.