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Updated: Feb 28, 2026

Advancing High-Resolution Imaging of Virus Assemblies in Liquid and Ice
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Advancing High-Resolution Imaging of Virus Assemblies in Liquid and Ice

Published on: July 20, 2022

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弥合结构差距:对代表性不足的病毒进行冷电子显微镜的方法审查

Yoon Ho Park1, Hyun Suk Jung1, Sungjin Moon2

  • 1Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea.

Viruses
|February 27, 2026
PubMed
概括

电子显微镜 (cryo-EM) 推进了结构病毒学,但脊椎动物病毒主导了数据. 新的方法旨在克服研究植物和昆虫病毒的障碍,提高我们对病毒多样性的理解.

关键词:
化电磁波是一种冷电磁波.它们是巨型病毒.昆虫病毒 昆虫病毒植物病毒 植物病毒脊椎动物病毒的病毒

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Cryo-electron Microscopy01:28

Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
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