雷姆德西维尔和奥贝尔德西维尔对2023年9月至2025年6月流通的SARS-CoV-2Omicron亚型的抗病毒活性
Lauren Rodriguez1, Jiani Li1, Dong Han1
1Gilead Sciences, Inc., Foster City, CA 94404, USA.
Viruses
|February 27, 2026
概括
雷姆德西维尔 (RDV) 和奥贝尔德西维尔 (ODV) 对新出现的SARS-CoV-2 Omicron变种保持强大的抗病毒活性. 这支持它们继续用于治疗COVID-19和开发新的口服抗病毒疗法.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- SARS-CoV-2 变种的出现需要持续监测抗病毒药物易感性.
- 雷姆德西维尔 (RDV) 和奥贝尔德西维尔 (ODV) 是SARS-CoV-2依赖RNA的RNA聚合酶 (Nsp12) 的抑制剂.
研究的目的:
- 评估RDV和ODV对新出现的SARS-CoV-2 Omicron亚型病毒的抗病毒活性.
- 评估新型NSP12替代品对抗病毒敏感性的影响.
主要方法:
- 使用各种Omicron亚型和野生类型参考菌株进行了抗病毒活性测定.
- 用基因组测序来识别新兴血统中的NSP12替代.
- 对具有观察到NSP12替代物的复制体进行了表型分析.
主要成果:
- 无论是RDV还是ODV,都显示出对多个Omicron亚型的抗病毒活性,包括BA.2.86.1,JN.1.7,KP.2,KP.3.1.1,KP.3.3,LP.8.1,NB.1.8.1,XBB.2,XEC和XFG.
- 在NB.1.8.1系中发现了一种新的NSP12替代物D284Y.
- 含有D284Y替代物的复制品仍然对RDV和ODV都敏感.
结论:
- RDV和ODV对目前流传的SARS-CoV-2 Omicron变种保持强大的活性.
- 这些发现支持RDV在COVID-19治疗中的持续临床应用.
- 作为一种有效的口服抗病毒治疗选择,ODV显示出前景.
关键词:
在 COVID-19 疫情中,Nsp12是什么意思 Nsp12是什么意思奥米克朗变种的变种这就是SARS-CoV-2病毒.基因型定制是基因型定制.在奥贝尔德塞维尔.现型定制 现型定制 现型定制雷梅西维尔 (remdesivir) 是一种药物.更多相关视频
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