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Updated: Feb 28, 2026

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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针对原型弗拉维病毒RNA-依赖RNA聚合酶的1'-和4'-氨基基基改性腺类比物

Simon M Walker1, Calvin J Gordon1, Egor P Tchesnokov1

  • 1Department of Medical Microbiology and Immunology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2E1, Canada.

Viruses
|February 27, 2026
PubMed
概括

两个核酸类似物remdesivir和GS-7682通过抑制病毒RNA聚合酶表现出抗病毒活性. 它们的活性形式表现出明显的抑制机制,remdesivir通常被证明比flaviviruses更优越.

关键词:
在GS-443902中使用.这是GS-64693939的产品.这是一种依赖RNA的RNA聚合酶.RdRpp 在线阅读广泛的抗病毒药物.弗拉维病毒 (flavivirus) 是一种病毒.核酸类比的核酸类比雷梅西维尔 (remdesivir) 是一种药物.

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