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Updated: Feb 28, 2026

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针对IL17A及其受体的aptamers抑制了不同细胞类型的IL17信号传递

Anastasiya Solovieva1, Dariya Rippinen1, Anna Davydova2

  • 1Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, 630117 Novosibirsk, Russia.

Pharmaceuticals (Basel, Switzerland)
|February 27, 2026
PubMed
概括

向INTERLEUKIN-17A (IL-17A) 和其受体的寡核酸聚体显示出作为治疗炎症关节病的单克隆抗体的替代品的希望. 在细胞模型中,这些胺酶有效地抑制了IL-17A诱导的炎症,这表明了脊髓关节炎治疗的潜力.

关键词:
它们的IL-17受体.一个aptamer的应用程序.纤维细胞类同胞细胞类似于纤维细胞.这是一种炎症炎症炎症炎症.介乐金-17A (IL-17A) 是一种蛋白质.类风湿性关节炎是一种类风湿性关节炎.脊柱性关节炎 (spondyloarthritis) 是一个疾病.

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