使用大植物化物作为天然聚合物用于持续释放Artemisia annua L. 烯酸提取物的胃部释放的飞形成系统的开发
Leila Ziaeifar1, Maryam Salami1,2,3, Gholamreza Askari1
1Department of Food Science, Engineering and Technology, College of Agriculture & Natural Resources, University of Tehran, Karaj Campus, Karaj 31587-77871, Iran.
Pharmaceutics
|February 27, 2026
概括
植物大粘液 (PMM) 增强了酸盐配方,改善了抗酸性能力和持续的药物释放. 经过优化的PMM木显示出优越的物理化学特性和长时间释放的基提取物.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 自然聚合物的应用 自然聚合物的应用
背景情况:
- 酸盐被用作抗酸剂,形成胃保持障碍,防止胃酸反流.
- 药物输送系统的目的是改善持续释放和胃保持.
- 研究天然聚合物,如Plantago主要粘液 (PMM),作为在配方中的合成聚合物的替代品.
研究的目的:
- 评估Plantago主要粘液 (PMM) 对酸盐属性的影响.
- 评估以PMM为基础的木作为持续释放药物输送系统.
- 为了比较PMM木与基于Carbomer的木.
主要方法:
- 在度0.5%和1%的合剂中,PMM被纳入酸盐制剂中.
- 分析了木的物理化学,机械和结构性质.
- 持续释放的Artemisia annua L.提取物,封装在子蛋白纳米颗粒中,在优化的木中进行了评估.
主要成果:
- 使用0.5%PMM的艇比碳合金艇具有更高的稳定性和更好的物理化学特性.
- 包括PMM增加了抗酸能力,胀,弹性,强度和凝硬度 (G').
- 经过优化的PMM,取物在体外释放时间延长,在6小时后累计释放<30%.
结论:
- 植物大粘液 (PMM) 是一种可行的天然替代品合成聚合物在酸盐配方.
- 基于PMM的酸盐提供了更好的抗酸效果和持续的药物输送能力.
- 优化的PMM系统有效地控制了内置的生物活性化合物的释放.
相关概念视频
01:11Oral Drug Delivery Systems: Delayed-Release Systems
69
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
69
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
269
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
269
01:22Modified-Release Drug Delivery Systems: Rate-Programmed I
53
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
53
01:26Oral Drug Delivery Systems: Continuous-Release Systems
77
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
77