通过设计实验,开发和评估含有黄素的粘粘膜膜,使用绿色深度环氧溶剂
Melike Zeynep Ünükür Sevim1,2, Muhammet Davut Arpa2, Kübra Kolci3,4
1Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Health Sciences, Istanbul 34668, Türkiye.
Pharmaceutics
|February 27, 2026
概括
绿色的深层欧性溶剂 (DES) 增强了黄素在新型口腔膜中的溶解性. 实验设计优化了持续释放和抗炎作用的配方,显示出局部药物输送的前景.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
背景情况:
- 黄素具有较差的溶解性,限制了其治疗应用.
- 开发有效的局部药物输送系统对于粘膜状况至关重要.
研究的目的:
- 使用绿色深层欧性溶剂 (DES) 制备含有黄素的口腔膜.
- 使用实验设计 (DoE) 优化膜配方,以提高溶解度和本地化交付.
- 评估开发的膜的体外和体外性能和生物活性.
主要方法:
- 准备和描述各种DES,以选择最佳的溶剂系统.
- 用于制造含有黄素的口腔膜的溶剂造方法.
- 应用中央复合材料设计 (DoE) 来优化薄膜组件 (HPMC K100,Kollicoat® IR,DES) 并评估关键反应 (粘膜粘合,胀等). ) 的情况.
- 在体外释放,体外透和生物活性测定 (抗炎,抗氧化,伤口愈合) 在优化的配方上进行.
主要成果:
- 胆化物:甘醇 (1: 4摩尔比) 被确定为最佳的DES,显著增加了黄素的可溶性.
- 成功制造黄素载荷的口腔膜,持续释放超过24小时.
- 优化的配方显示出良好的粘膜粘附性,胀性和细胞兼容性.
- 活体研究显示粘膜透率最小 (<2%),表明局部作用.
- 观察到显著的体外抗炎,抗氧化和伤口愈合生物活性.
结论:
- 绿色DES辅助配方策略,在能源部的指导下,成功开发了含有黄素的口腔膜.
- 开发出来的片具有有利的物理化学性质,并具有有前途的体外生物活性.
- 这种配方平台为局部口腔药物递送应用提供了一种可行的方法.
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