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Updated: Feb 28, 2026

In Vitro Permeation of FITC-loaded Ferritins Across a Rat Blood-brain Barrier: a Model to Study the Delivery of Nanoformulated Molecules
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新生儿Fc受体对转移素受体抗体的影响融合蛋白质药理动力学

Adenike Oyegbesan1, Nataraj Jagadeesan1, Devaraj V Chandrashekar1

  • 1Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA 92618, USA.

Pharmaceutics
|February 27, 2026
PubMed
概括

融合合作伙伴会影响新生儿Fc受体 (FcRn) 对转移素受体向单克隆抗体 (TfRMAbs) 的处理,从而影响它们的大脑药物递送的药理动力学. 慢性剂量揭示了影响TfRMAb暴露的FcRn和之外的机制.

关键词:
在FcRn中介的回收过程中.血脑屏障是什么意思大脑药物输送大脑药物输送新生儿的Fc受体.转移素受体抗体是转移素受体的抗体.

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