左心室和双心室多点节奏与动态心房延迟: 6个月的心脏再同步治疗反应反应
Bernard Thibault1, Peter Waddingham2, Nima Badie3
1From the Electrophysiology Service, Montreal Heart Institute, Université de Montréal, Montreal, Canada.
Journal of cardiovascular electrophysiology
|February 27, 2026
概括
将SyncAV CRT与多点节奏 (MPP) 结合起来,对心脏再同步治疗患者显示出有希望的6个月结果. 双心室和LV-only节奏都改善了心声学和临床结果.
科学领域:
- 心脏病学 心脏病学
- 医疗器械 医疗器械
- 临床试验 临床试验
背景情况:
- 心脏再同步治疗 (CRT) 的反应因节奏位置和时间而异.
- 动态心房 (AV) 延迟 (SyncAV CRT) 和多部位左心室 (LV) 节奏 (MPP) 可能改善CRT结果.
- 在慢性情况下,SyncAV和MPP的联合作用尚未得到充分研究.
研究的目的:
- 评估SyncAV与双心室MPP (MPP+SyncAV) 或LV-only MPP (LVMPP+SyncAV) 结合的6个月心声回应和临床反应.
主要方法:
- 一项多中心研究随机选择了CRT指示的患者,他们有LBBB和完整的AV导电.
- 患者接受了MPP+SyncAV (RV+LV1+LV2节奏) 或LVMPP+SyncAV (LV1+LV2节奏).
- 优化了syncAV偏移以最大限度地减少QRS持续时间;在基线和6个月评估了心声回声和临床指标.
主要成果:
- 70名患者完成了该研究 (MPP+SyncAV:n=36;LVMPP+SyncAV:n=34).
- 这两组在6个月后,LV末缩体积 (ESV) 和LV射出分数 (EF) 的改善相似.
- 对于NYHA类,生活质量 (QoL) 和Packer分数在两组中都观察到类似的积极趋势.
结论:
- 将SyncAV与MPP (双心室或仅LV) 结合使用,在LBBB患者中显示出有希望的6个月心声和临床反应率.
- 这些发现表明,这种对CRT的综合节奏策略具有潜在的好处.
- 进一步的研究可能会探索长期结果和更广泛的患者群体.
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