婴儿时期的和随后的喘发育:有联系吗?
Ju Hee Kim1, Ja Kyoung Kim2, Jin Sung Park2
1Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, Korea.
概括
儿童的重复性形可能标志着晚年患喘的风险更高. 一个单一的发作没有显示这种关联,但多个发作确实有,特别是在过敏的儿童中.
科学领域:
- 儿科呼吸系统医学 儿科呼吸系统医学
- 流行病学 流行病学
- 过敏和免疫学的过敏和免疫学.
背景情况:
- 是幼儿常见的呼吸道疾病,通常会自发消失.
- 史与儿童喘风险之间的潜在联系需要进一步调查.
研究的目的:
- 调查病史与随后患儿喘的风险之间的关联.
- 为了确定反复发生的形发作是否会比单次发作增加喘风险.
主要方法:
- 一项全国性基于人口的队列研究,使用韩国国家医疗保险服务数据库.
- 包括2008-2012年间出生的儿童,病例与对照病例相匹配.
- 基于代码,药物或住院的喘诊断,随访至2021年.
主要成果:
- 病史与喘风险的轻微增加有关 (aHR为1.07).
- 复发性 (≥2次发作) 显著增加了喘风险 (aHR为1.41),而单次发作则没有.
- 这种联系在患有同时存在的亚托皮性疾病的儿童中最为强烈.
结论:
- 反复发作,而不是单次发作,与随后喘风险的增加有关.
- 复发性形可能是喘易感性的早期临床指标.
- 这种关联在患有同时存在的亚托皮性疾病的儿童中尤为明显.
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