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细菌学检测在肺外结核病中未得到充分利用:来自土耳其马丁的一个回顾性单中心研究
Barış Çil1, Mehmet Sinan Bodur2, Mehmet Kabak3
1Clinic of Pulmonology, Mardin Training and Research Hospital, Mardin, Türkiye.
外肺结核 (EPTB) 诊断具有挑战性,细菌学确认率低,测试使用不足. 改善采样和分子检测对于准确的EPTB诊断至关重要.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 肺外结核 (EPTB) 由于细菌负载较低,因此存在诊断困难.
- 对EPTB的细菌学测试通常是有限的,影响了准确的诊断.
研究的目的:
- 为了评估EPTB的细菌学确认率.
- 评估土耳其EPTB病例的诊断方法和采样实践.
主要方法:
- 在2014-2019年间诊断的456例结核病 (TB) 病例的回顾性分析.
- 病例的分类为肺结核 (PTB),EPTB和混合参与.
- 在PTB和EPTB组之间比较细菌学和组织病理学确认率.
主要成果:
- EPTB占41.0%的病例,淋巴结结核结核是最常见的 (22.4%).
- 与PTB (AFB涂抹71.4%,培养66.5%) 相比,EPTB (AFB涂抹3.2%,培养4.3%) 的细菌学确认明显较低.
- 组织病理学确认在EPTB中很高 (88.8%),但没有从63.1%的EPTB患者收集细菌学样本.
结论:
- 细菌学测试在EPTB诊断中使用不足且效率低下.
- 组织病理学是该队列中EPTB的主要诊断方法.
- 改进的采样策略和快速分子测试对于改善EPTB细菌学验证至关重要.
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