大麻使用障碍的多基因风险与双相情感障碍和没有双相情感障碍的年轻人中大脑结构的关联
Alysha A Sultan1, Clement C Zai1,2,3, Kody G Kennedy1
1Centre for Youth Bipolar Disorder, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Journal of psychopharmacology (Oxford, England)
|February 27, 2026
概括
大麻使用障碍 (CUD) 的更高遗传风险与青少年的大脑结构的减少有关,即使没有诊断的CUD. 这表明遗传倾向会影响神经发育.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
背景情况:
- 大麻使用障碍 (CUD) 在青少年中普遍存在,特别是那些患有双极性障碍 (BD) 的青少年.
- 青少年使用大麻与不典型的大脑结构有关.
- 对CUD的遗传倾向可能会影响这些神经结构差异.
研究的目的:
- 调查CUD (CUD-PRS) 的多基因风险得分与患有BD和没有BD的青少年的大脑结构之间的关系.
- 探索与大麻使用相关的神经结构变异的遗传贡献.
主要方法:
- 利用了114名参与者的T1加权MRI扫描 (年龄为13-20岁;67名BD,47名健康对照).
- 使用PRS-CS-auto根据成年GWAS总结统计数据计算CUD-PRS.
- 进行了对共变量调整的顶点分析,以评估CUD-PRS与皮质体积,表面积和厚度的关联.
主要成果:
- 在总体样本中,CUD-PRS升高与右上额头回体的体积和表面积减少相关.
- 较高的CUD-PRS也与左侧偏中心叶片的表面积减少有关.
- 在健康对照组中,增加的CUD-PRS与双边上部额叶回道的体积和表面积较低有关;在BD组中没有发现显著的关联.
结论:
- 研究结果表明,无论CUD诊断如何,高CUD-PRS和降低区域大脑结构之间存在一致的关联.
- 需要进一步的研究来阐明这些神经结构发现的潜在机制,发育途径和诊断变异.
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