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Updated: Feb 28, 2026

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
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与AML相关的核胺C终端 (NPM1) 的多位化调节蛋白质稳定性,DNA结合和电荷块驱动的相分离

Pablo Rivero-García1, Rafael L Giner-Arroyo1, Joaquín Tamargo-Azpilicueta1

  • 1Institute for Chemical Research-cicCartuja, University of Seville-CSIC, 41092 Seville, Spain.

Nucleic acids research
|February 27, 2026
PubMed
概括

核胺 (NPM1) 的酸化削弱了其DNA结合和液-液相分离. 这解释了NPM1突变如何导致其在急性髓性白血病 (AML) 中的细胞质外定位.

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