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Updated: Feb 28, 2026

Antibiotic Dereplication Using the Antibiotic Resistance Platform
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G1405 利博索姆甲基转移酶驱动的抗菌耐药性影响了4,5-失置-2-脱氧斯特胺类的氨基甘油酸抗生素

Sven N Hobbie1, Andrea Vasella2, Erik C Böttger1

  • 1Institute of Medical Microbiology, Universität Zürich, Gloriastrasse 30, Zürich CH-8006, Switzerland.

JACS Au
|February 27, 2026
PubMed
概括

改性氨基糖化物 (AGAs) 可以受到核糖体甲基转移酶的影响,这与之前的看法相反. 药物修改和甲基化可以降低抗菌活性,影响未来的抗生素发现.

关键词:
氨基糖化物抗生素是一种抗生素.抗菌耐药性的抗菌药物.在这种情况下,apramycin会产生.多种药物耐药性多种药物耐药性核糖体中的甲基转移酶.

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