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Updated: Feb 28, 2026

Using Scaffold Liposomes to Reconstitute Lipid-proximal Protein-protein Interactions In Vitro
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酸酶的小分子激活剂PP2A重塑脚手架PR65结构动力学促进全酶组装

Sema Z Yilmaz1, Anupam Banerjee2,3, Satyaki Saha2,3

  • 1Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.

JACS Au
|February 27, 2026
PubMed
概括

针对PP2A子单元PR65的小分子激活剂 (SMAP) 显示出用于癌症治疗的潜力. 模拟显示SMAPs在S2位点稳定地与PR65结合,而不是S1,从而影响PP2A激活.

关键词:
激活器绑定绑定 激活器绑定绑定网站 绑定网站结合诱导的形状变化分子动力学模拟,分子动力学模拟一起重复蛋白质的同时重复蛋白质.

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