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Updated: Feb 28, 2026

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery
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Published on: May 2, 2019

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服阿基里斯的脚跟:一种化学和结构设计,以解决siRNA治疗中的非目标效应

Rohith Pavan Parvathaneni1, Nithiyanandan Krishnan2, Nikolai Hempel3

  • 1Translational Chemical Biology, Science for Life Laboratory, Department of Chemistry, Ångström Laboratory, Uppsala University, 751 21 Uppsala, Sweden.

JACS Au
|February 27, 2026
PubMed
概括

这项研究引入了对小干扰RNA (siRNA) 的新化学修饰,以减少意外相互作用. 这一策略增强了RNA干扰 (RNAi) 的特异性,同时保持了它的有效性.

关键词:
化学修饰是一种化学修饰.在RISC中加载RISC.结构修改是指结构的修改.热力学不对称性是热力学不对称性的.siRNA 是一个RNA.

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