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Updated: Feb 28, 2026

The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli
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通过化学酶合成14个成员的宏类的结构多样化

Brian J Curtis1, Hannah A Boesger1,2, Jennifer J Schmidt1

  • 1Life Sciences Institute, University of Michigan, Mary Sue Coleman Hall, 210 Washtenaw Avenue, Ann Arbor, Michigan 48109-2216, United States.

JACS Au
|February 27, 2026
PubMed
概括

研究人员探索了皮克罗米多基酸合成酶 (PKS) 系统,以创建新的抗生素支架. 这项研究有效地多样化了麦克罗拉克顿,并通过化学酶合成确定了新的乳.

关键词:
在 C−H 功能化中.化学酶合成的化学酶合成密度函数理论密度函数理论宏观循环的支架 宏观循环的支架分子动力学模拟,分子动力学模拟皮克罗米辛路径的路径聚基化合成酶的使用.

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