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Updated: Feb 28, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
07:59

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

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通过结构引导理性设计的P450工程实现了在类固醇生物合成中的高C21选择性和生物转化

Jian Yang1, Rong Li1, Qilin Gao1

  • 1College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, Zhejiang, 310018, China.

Synthetic and systems biotechnology
|February 27, 2026
PubMed
概括

为高效的皮质类固醇合成设计了一种细菌酶,实现了对孕激素C21-基化的区域选择性转移. 这种生物催化剂提供了增强的类固醇生产和对酶工程的洞察力.

关键词:
C21 氧化化弗里斯姆是一个自由主义者.在P450中,P450是什么?理性的设计理性的设计.区域活动性 区域活动性类固醇是一种类固醇.

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