综合生物信息分析识别了侵袭性阿斯伯吉洛症中与铁亡相关的生物标志物和亚型
Lu Tang1, Luying Yang2, Weiwei Qian3
1The Department of Respiratory and Critical Care Medicine, Shangjinnanfu Hospital, West China Hospital, Sichuan University, No. 253 Shangjin Road, Gaoxin West District (Pidu Hongguang), Chengdu, Sichuan Province 611730, China.
Toxicology research
|February 27, 2026
概括
铁,一种依赖于铁的细胞死亡,在侵袭性阿斯伯吉洛症 (IA) 中起着关键作用. 这项研究确定了五个与铁亡相关的基因作为IA的诊断生物标志物,揭示了疾病亚型和免疫相互作用.
科学领域:
- 菌类学 菌类学是指菌类学.
- 免疫学 免疫学 免疫学
- 计算生物学 计算生物学
背景情况:
- 侵入性阿斯伯吉洛症 (IA) 是一种严重的真菌感染,其机制尚不清楚.
- 铁亡的作用,一种调节细胞死亡的形式,在IA的病原发生中基本上未被探索.
研究的目的:
- 通过生物信息学研究铁和IA之间的关联.
- 确定与铁灭相关的基因 (FRG) 作为IA的潜在诊断生物标志物.
主要方法:
- 对差异表达基因 (DEGs) GSE78000数据集的分析.
- 策划了FRG,构建了蛋白质-蛋白质相互作用 (PPI) 网络,并进行了基因本体学 (GO) 和KEGG通路分析.
- 利用机器学习算法 (SVM,LASSO,随机森林) 来识别核心FRG和ssGSEA用于免疫细胞透分析.
主要成果:
- 五个核心FRG (KIF20A,PEBP1,HMOX1,MTF1,QSOX1) 被鉴定出具有很高的诊断准确性 (AUC:0.884-0.981).
- 对IA患者进行分类,分为两种不同的与铁亡相关的亚型 (C1,C2),具有独特的分子配置和途径丰富.
- 观察到免疫细胞透的显著变化,与核心FRG表达相关的先天性免疫细胞增加和适应性免疫细胞减少.
结论:
- 铁致死在IA的病变发生过程中发挥了关键作用.
- 已确定的核心FRG是IA的有希望的诊断生物标志物.
- 这项研究为IA异质性,铁亡作用及其与免疫微环境的相互作用提供了新的见解,表明了潜在的治疗点.
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