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益生菌补充剂调节肠道微生物群,改善儿科耐火性喘的临床结果
Zheng Liu1, Wen Deng2, Wenlin Xu2
1Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents Health and Diseases, Ministry of Education, Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Chongqing, China.
多菌株益生菌显著改善了耐性喘儿童的喘控制和肠道健康. 这种肠肺轴疗法为治疗儿科喘提供了一种有前途的新方法.
科学领域:
- 儿科肺病学 儿科肺病学
- 微生物组研究 微生物组研究
- 免疫学 免疫学 免疫学
背景情况:
- 儿童耐火性喘是一个重大的临床挑战.
- 肠道微生物组失调症越来越多地与通过肠肺轴的持续性炎症有关.
研究的目的:
- 调查多菌株益生菌补充剂作为儿科耐火性喘辅助治疗的疗效.
- 评估益生菌对喘控制,肺功能和肠道微生物平衡的影响.
主要方法:
- 一项前性随机对照试验,涉及88名患有耐火性喘的儿童 (4至8岁).
- 传统疗法与传统疗法加上多菌株益生菌 (Bifidobacterium,Lactobacillus acidophilus,Streptococcus thermophilus) 的4个月的比较.
- 评估喘控制 (喘控制测试得分),肺功能 (FEV1,FVC,PEF) 和肠道微生物群组成 (16S rRNA基因测序).
主要成果:
- 组合疗法导致完全控制喘率显著提高 (68.18%对36.36%),并改善了喘控制测试成绩.
- 在益生菌组中观察到FEV1,FVC和PEF的优异改善.
- 益生菌补充剂导致肠道微生物α多样性的增加和有益的转变,包括增加Bifidobacterium和减少Bacteroides.
结论:
- 辅助的多菌株益生菌可提高儿科耐性喘患者的临床结果和肠道微生物群健康.
- 这支持通过肠肺轴作用的针对微生物组的治疗方法.
- 需要进行更大规模的试验来确认长期益处.
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