在代谢功能障碍相关的脂肪性肝病谱中的生物衰老:系统性审查
Chukwuemeka E Ogbu1, Stella C Ogbu1, Chidera P Ogbu2
1Internal Medicine Residency Program, Cape Fear Valley Health, Fayetteville, NC 28304, USA.
iLIVER
|February 27, 2026
概括
加快的生物衰老增加了与代谢功能障碍相关的脂肪性肝病 (MASLD) 风险,纤维化和死亡率. 为了在MASLD中获得临床相关性,需要标准化的衰老措施.
科学领域:
- 老年学是指老年学的学科.
- 肝病学 肝病学是一种肝病学.
- 慢性疾病流行病学 慢性疾病流行病学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个重大的,不断升级的全球健康挑战.
- 气质科学强调加速生物衰老 (BA) 是慢性疾病的主要原因.
- 了解BA在MASLD频谱中的作用对于疾病管理至关重要.
研究的目的:
- 系统地审查和综合关于生物衰老 (BA) 在代谢功能障碍相关的脂肪性肝病 (MASLD) 中的作用的证据.
- 定义BA的各种措施与MASLD风险,进展和结果的关系.
主要方法:
- 在主要数据库 (PubMed/MEDLINE,Embase) 进行了系统的文献搜索,以寻找观察性研究.
- 包括的研究评估了成熟的BA措施 (例如,表观遗传时钟,端粒长度,表型年龄) 在成年人与MASLD结果.
- 由于方法的异质性,采用了叙事合成.
主要成果:
- 十九项研究表明,加速BA与MASLD/非酒精性脂肪肝疾病 (NAFLD) 的更高几率有关.
- 较高的基线BA预测了发生NAFLD的风险增加,并且与MASLD患者的纤维化和死亡率增加有关.
- BA可能会调解MASLD的环境毒性影响,并通过遗传/环境因素改变风险.
结论:
- 加快的生物衰老始终与增加的MASLD/NAFLD风险,纤维化和死亡率相关.
- 在MASLD中,BA可以作为临床相关的风险整合剂.
- 需要在纵向研究中协调BA措施,以提高可比性和临床应用.
关键词:
生物年龄 生物年龄基因表观时钟是什么?纤维化 纤维化 纤维化地质科学是地球科学.克莱梅拉-杜巴尔方法马斯尔德 马斯尔德是什么意思死亡率 死亡率 死亡率这是NAFLD.纳什·纳什 (Nash Nash) 是一个名为纳什的城市.现型年龄 现型年龄系统性审查 系统性审查更多相关视频
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