糖尿病是发生CMV视网膜炎的危险因素 固体器官移植受体:一种病例对照研究
Dilpreet K Bharaj1, Shanil Dhanji2, Elena Gurung2
1Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Open forum infectious diseases
|February 27, 2026
概括
细胞巨乳病毒视网膜炎 (CMVR) 是固体器官移植 (SOT) 接受者的罕见并发症. 糖尿病显著增加了SOT后CMVR发展的风险.
科学领域:
- 眼科医生 眼科 眼科
- 移植手术 移植手术
- 传染性疾病 传染性疾病
背景情况:
- 固体器官移植 (SOT) 接受者的长期存活率的改善可能会增加细胞巨乳病毒视网膜炎 (CMVR) 的发生率.
- 在SOT后的CMVR流行病学需要进一步阐明.
- 这项研究调查了SOT接受者的CMVR发生率和风险因素.
研究的目的:
- 在SOT接收者中确定CMVR的发生率.
- 确定与SOT后的CMVR发展相关的风险因素.
- 评估糖尿病和CMVR风险之间的关联.
主要方法:
- 从2012年1月到2024年3月进行了一项1:4比例的病例控制研究.
- 病例是被诊断患有CMVR的SOT接受者;对照组根据器官,年龄和中心进行了匹配.
- 条件后勤回归模型用于单变量和多变量分析.
主要成果:
- 在5877名SOT接受者中,CMVR的发病率为每1万人年5.3人.
- 与对照人群相比,CMVR病例年龄较大,患糖尿病 (DM) 和CMVDNAemia的可能性更高.
- 糖尿病 (DM) 独立地与CMVR的几率增加有关 (OR 16.5).
结论:
- 在SOT之后,CMVR是一种罕见的,晚发症的并发症.
- 糖尿病是SOT接受者中CMVR的重要独立风险因素.
- 对糖尿病SOT患者管理CMVR风险的进一步研究是有必要的.
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