一个回顾性临床分析不适当的西安丹注射使用:临床风险分析和计算假设生成
Ji Zeng1, Yougang Wei2, Jinke Zhang2
1Clinical Pharmacy Department, Department of Pharmacy, Ma'anshan City Hospital of Traditional Chinese Medicine, Ma'anshan, Anhui, China.
Frontiers in pharmacology
|February 27, 2026
概括
丹注射剂由于不合理使用,造成安全风险,包括不明确的指示和长期治疗. 计算分析表明,黄素可能针对AKT1和PTGS2,突出显示了潜在的肝毒性问题.
科学领域:
- 药理学 药理学是指药理学的学科.
- 传统中国医药 传统中国医药
- 计算生物学 计算生物学
背景情况:
- 丹注射是一种广泛使用的传统中医药 (TCM) 准备.
- 丹注射的不适当使用引发了严重的临床安全问题.
- 了解分子基础和识别与TCM使用相关的风险至关重要.
研究的目的:
- 在临床实践中识别丹注射药物不理性的药物使用模式.
- 使用计算方法生成关于丹注射的潜在生物活性成分和分子途径的假设.
- 提出改善丹注射安全临床应用的策略.
主要方法:
- 对接受丹注射的100例患者病例的回顾性分析.
- 专注的审查,以评估西安丹注射使用的理由.
- 网络药理学和分子对接,用于对生物活性化合物和标进行探索性分析.
主要成果:
- 确定了四种不合理使用的主要模式:不明确的指示 (67.8%),不适当的溶剂 (16.1%),重复服用药物 (11.3%) 和长时间使用 (4.8%).
- 网络药理学表明,像黄素这样的关键代谢物可能准AKT1和PTGS2,可能涉及PI3K/AKT通路.
- 分子对接显示了luteolin和PTGS2之间的潜在结合亲和;与肝脏过程相关的代谢物表明潜在的肝毒性风险.
结论:
- 这项研究确定了与丹注射不合理的临床使用相关的关键风险模式.
- 计算分析为丹注射成分的药理特征和潜在毒性提供了初步假设.
- 提出了有针对性的建议,以提高临床环境中丹注射的安全性.
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