通过肠道载体介导的塔利诺洛尔的区域吸收:PBPK建模分析的见解

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Updated: Feb 28, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

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Kazuya Ishida1, Xiaomin Liang1, Fulden Buyukozturk2

  • 1Drug Metabolism, Gilead Sciences, Inc., Foster City, CA, United States.

Frontiers in pharmacology
|February 27, 2026
PubMed
概括

肠道载体的区域差异解释了双重药物吸收峰值. 建模表明,特定肠道区域的输送器活性是理解复杂药物度-时间概况的关键.

关键词:
这是一种P-glycoprotein蛋白.毒品运输商 毒品运输商肠道吸收 肠道吸收基于生理学的药物动力学模型.塔利诺醇的使用方法

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