身体圆度指数与汉族妇女不孕症风险之间的关联:一项追溯观察性研究
Nizhou Liu1, Xingyu Sun2, Lijuan He3
1Department of Reproductive Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Frontiers in medicine
|February 27, 2026
概括
较高的身体圆度指数 (BRI) 与汉族女性不孕症风险增加有关. 这种风险随着中心脂肪水平的提高而显著升级,这表明BRI.
科学领域:
- 生殖健康 生殖健康
- 人类测量学 人类测量学.
- 代谢健康 代谢健康
背景情况:
- 不孕症是一个全球性的健康问题,受代谢和人类学因素的影响.
- 身体圆度指数 (BRI) 是衡量中心脂肪的指标,与心脏代谢结果有关.
- 关于BRI与不孕症的关联,特别是非线性影响的证据有限.
研究的目的:
- 为了调查BRI与汉族女性不孕症风险之间的关联.
- 探索潜在的非线性关系和BRI和不孕不育的子组特定模式.
主要方法:
- 对425名汉族女性 (20至44岁) 的回顾性观察研究.
- 从腰围和身高计算BRI;不孕症被定义为12个月的无保护性交.
- 用于评估关联和非线性趋势的多变量逻辑回归和受限立方线.
主要成果:
- 患有不孕症的女性比对照组 (7.1 ± 1.5) 的BRI显著更高 (8.5 ± 2.0).
- 每个单位增加的BRI与更高的不育率相关 (aOR=1.38).
- 观察到非线性关联,风险急剧上升至BRI 8.0以上;在老年女性,高BMI,PCOS或低收入女性中观察到更强烈的效应.
结论:
- 升高的BRI与汉族女性不孕症风险增加有关.
- 存在非线性剂量反应关系,在较高的BRI水平下,风险加快.
- BRI可能有助于不孕症风险分层,这需要进一步的前性研究.
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