相关实验视频

Updated: Feb 28, 2026

Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions
10:53

Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions

Published on: November 9, 2020

5.6K

OmniCellTOSG:图形语言基础建模的第一个细胞文本-奥米信号图形数据集

Fuhai Li, Heming Zhang, Tim Xu

    Research square
    |February 27, 2026
    PubMed
    概括

    研究人员开发了一种新的数据结构,即文本-欧米信号图 (TOSG),以将生物医学知识与欧米数据集成. 这使得一个强大的基础模型 (FM) 可用于增强生命科学和精密医学研究.

    更多相关视频

    Databases to Efficiently Manage Medium Sized, Low Velocity, Multidimensional Data in Tissue Engineering09:43

    Databases to Efficiently Manage Medium Sized, Low Velocity, Multidimensional Data in Tissue Engineering

    Published on: November 22, 2019

    6.8K
    Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues10:12

    Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues

    Published on: January 10, 2019

    19.2K

    相关概念视频

    Overview of Cell Signaling01:23

    Overview of Cell Signaling

    Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
    Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
    25.4K
    IP3/DAG Signaling Pathway01:11

    IP3/DAG Signaling Pathway

    Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the  phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and...
    15.2K
    Hedgehog Signaling Pathway02:33

    Hedgehog Signaling Pathway

    The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
    10.2K
    Nitric Oxide Signaling Pathway01:28

    Nitric Oxide Signaling Pathway

    Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
    6.5K
    What is Cell Signaling?02:03

    What is Cell Signaling?

    Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
    131.7K
    Calmodulin-dependent Signaling01:16

    Calmodulin-dependent Signaling

    Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
    The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
    6.7K