利多卡因和德克斯梅托米丁在预防接受选择性手术的患者的芬太尼诱导咳中的比较:一个盲目的随机对照试验
Hashem Jarineshin1, Hananeh Zarezadeh2,3, Sara Ghazizadeh4
1Department of Anesthesiology, Critical Care and Pain Management Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
利多卡因 (LIDO) 和德克斯梅德托米丁 (DEX) 同样可以预防芬太尼引起的咳 (FIC). 在接受手术的患者中,DEX比LIDO更能抑制血液动力学参数.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 芬太尼诱导咳 (FIC) 是芬太尼的常见副作用,芬太尼是一种阿片类止痛药.
- 已知利多卡因 (LIDO) 和德克斯梅托米丁 (DEX) 可以预防FIC,但它们的比较疗效需要进一步研究.
研究的目的:
- 为了比较LIDO与DEX在接受选择性手术的成年患者中预防FIC的疗效.
- 评估LIDO和DEX在FIC预防期间对血液动力学参数的影响.
主要方法:
- 一个盲目的,随机的,安慰剂控制的试验,涉及171名成年患者 (ASA类I或II).
- 在服用芬太尼之前,患者接受了DEX (0.5μg/kg),LIDO (1.5 mg/kg) 或安慰剂盐水.
- 在注射芬太尼后,对咳的发生率和严重程度以及血液动力学参数进行了监测.
主要成果:
- 与安慰剂 (33.3%) (P < 0.001) 相比,在DEX (7.0%) 和LIDO (10.5%) 组中,FIC的发生率显着较低.
- 在DEX和LIDO组之间没有观察到FIC预防的显著差异 (P = 0.453).
- 与LIDO (P < 0.001) 相比,DEX的使用导致心率,心压和心压下降更明显 (P < 0.001).
结论:
- 德克斯和利多在预防芬太尼引起的咳方面同样有效.
- 德克斯梅德托米丁导致血液动力学参数的抑制比利多卡因更为显著.
- 在FIC预防中选择DEX和LIDO之间的选择可能取决于所需的血液动力学效应.
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