病例报告:非典型的神经乱性恶性综合征诱导的帕利佩里顿palmitate-诊断挑战和临床考虑
Omar El Oumary1,2, Hicham Laaraj1, Mina Ouhamou1
1Department of Psychiatry, Faculty of Medicine, Ibn Zohr University, Agadir, Morocco.
Frontiers in psychiatry
|February 27, 2026
概括
长效注射抗精神病药物很少会导致神经乱性恶性综合征 (NMS),这是一个严重的疾病. 这一案例凸显了诊断方面的挑战,以及对接受这些治疗的精神分裂症患者的NMS监测的必要性.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 神经学 神经学
背景情况:
- 治疗坚持不良是精神分裂症管理的一个重要问题.
- 长效注射 (LAI) 抗精神病药物用于改善坚持,但存在风险.
- 神经乱性恶性综合征 (NMS) 是一种罕见但严重的与抗精神病药物相关的不良事件.
研究的目的:
- 报告精神分裂症患者的非典型神经乱性恶性综合征 (NMS) 病例,该患者接受了长效注射巴利皮里棕酸盐治疗.
- 突出在LAI抗精神病药的背景下,NMS所带来的诊断和治疗挑战.
- 强调在接受LAI配方的患者中对NMS的警监测的重要性.
主要方法:
- 一个病例报告,一名51岁的精神分裂症男性患者在接受帕利皮里棕酸盐后出现了临床恶化.
- 临床表现包括高温症,低心率,肌肉刚性,困惑和肌酸酸酶的升高.
- 诊断评估包括排除传染性触发因素和监测实验室异常.
主要成果:
- 患者在LAI给药后出现了与非典型NMS呈现一致的症状.
- 最初的抗生素治疗是无效的,但在ICU中的症状管理导致了逐渐改善.
- 五周后,患者完全康复,随后患者可以很好地忍受奥兰扎平.
结论:
- 与LAI抗精神病药物相关的NMS存在诊断和治疗方面的挑战.
- 对于接受长效注射抗精神病药物的患者来说,密切和长时间的监测至关重要.
- 这一案例强调了需要提高对LAI治疗的精神分裂症患者的NMS,特别是非典型形式的认识.
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