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Updated: Feb 28, 2026

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
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DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

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定向演化T7RNA聚合酶最小化dSRNA副产品,并使高保真性mRNA合成为苛刻的治疗应用

Weitong Qin1, Ting Nie1, Mohan Hei1

  • 1State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.

Research (Washington, D.C.)
|February 27, 2026
PubMed
概括

工程T7RNA聚合酶 (T7RNAP) M30在mRNA合成中减少双链RNA副产品. 这种M30变体改善了治疗mRNA的产生,具有更高的效率和更低的免疫性.

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