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Updated: Feb 28, 2026

Design and Analysis of Temperature Preference Behavior and its Circadian Rhythm in Drosophila

Design and Analysis of Temperature Preference Behavior and its Circadian Rhythm in Drosophila

Published on: January 13, 2014

"THERM-D"揭示了分离Drosophila的早晨和晚上的体温节律的独特神经机制

Tadahiro Goda, Olivia M Lopez, Richard Ramolete

bioRxiv : the preprint server for biology

|February 27, 2026

概括

动物的体温节奏是由不同的时钟神经元电路调节的. 密码染色体负的神经元特别控制果的早晨温度升高,与睡眠-觉醒周期分开.

科学领域:

时间生物学时间生物学
神经科学是一个神经科学.
动物生理学动物生理学

背景情况:

身体温度节律 (BTR) 在白天活动的物种中保持不变,但潜在的机制尚不清楚.
时钟神经元调节昼夜节律,但它们在BTR中的特定作用尚未完全理解.

研究的目的:

为了研究驱动体温节律 (BTR) 的机制,在白天活动的动物.
为了确定CRYPTOCHROME (CRY) 负时钟神经元在调节BTR.的作用.

主要方法:

开发一个机器学习平台,THERM-D (Drosophila模型中节律性温度恒温评估),用于高通量BTR分析.
利用新开发的Gal4驱动器来准和研究Drosophila中的CRY负时钟神经元.

主要成果:

在Drosophila中确定了强大的BTR模式,与早上和晚上的行为有关.
证明CRY负时钟神经元特别调节早晨的温度升高.
表明这些神经元不会影响晚上BTR,这表明早上和晚上调节的单独电路.

结论:

单独的时钟神经元电路调节体温节律的不同阶段.
阴性CRY时钟神经元在早晨BTR调节中起着特殊的作用,独立于睡眠和清醒周期.

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Circadian Entrainment of Drosophila Melanogaster

Circadian Entrainment of Drosophila Melanogaster

Published on: June 3, 2020

A Temperature Gradient Assay to Determine Thermal Preferences of Drosophila Larvae

A Temperature Gradient Assay to Determine Thermal Preferences of Drosophila Larvae

Published on: June 25, 2018

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Circadian Rhythms and Gene Regulation

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...