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Updated: Feb 28, 2026

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过度依赖Ca2+的ER-线粒体接触稳定由EFHD1驱动肝损伤

David R Eberhardt, Emma C Rekate, Yasmin B Masini

    bioRxiv : the preprint server for biology
    |February 27, 2026
    PubMed
    概括

    EFHD1蛋白稳定了内分泌网膜-线粒体接触部位,但其在代谢相关脂肪肝炎 (MASH) 中的上调会导致肝损伤. 抑制EFHD1可以减少肝细胞损伤,这表明MASH的新治疗策略.

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