一种受当地启发的西弗吉尼亚肥胖饮食诱导脂肪积累和代谢功能障碍,同时识别性别差异
bioRxiv : the preprint server for biology
|February 27, 2026
概括
一种新的西弗吉尼亚肥胖饮食 (WV-OD) 有效地模拟了雄性小鼠的饮食诱导肥胖症,显示了与高脂肪饮食相似的代谢干扰,但具有区域差异. 雌性小鼠对WV-OD有弹性,突出了基于性别的差异.
科学领域:
- 营养科学 营养科学
- 代谢研究研究 代谢研究
- 肥胖研究 肥胖研究
背景情况:
- 美国肥胖率的上升,特别是在西弗吉尼亚州.
- 需要特定区域的饮食模型来研究代谢效应.
- 现有的高脂肪饮食 (HFD) 模式的局限性.
研究的目的:
- 为临床前研究开发和验证西弗吉尼亚肥胖性饮食 (WV-OD).
- 比较WV-OD对控制和HFD在小鼠中的代谢效应.
- 调查对WV-OD的反应中的基于性别的差异.
主要方法:
- 区域饮食的组成分析,以创建WV-OD.
- 养雄性和雌性C57BL/6J小鼠WV-OD,控制饮食 (WV-CD) 或HFD19周.
- 评估体重增加,肥胖,耐葡萄糖,肝脂,胆固醇,尿酸和丁氧降解酶 (XOR).
主要成果:
- 在雄性小鼠中,WV-OD诱导了体重增加,肥胖,葡萄糖不耐受和肝肥胖症,与HFD相似.
- 在WV-OD的雄性小鼠中,血液中的胆固醇水平升高,而肝脏水平没有增加.
- WV-OD没有增加尿酸或XOR,但显示了血尿酸升高的趋势;女性没有显著的代谢功能障碍.
- 观察到对WV-OD代谢反应的性别差异.
结论:
- WV-OD是一种经过验证的工具,用于建模饮食引起的肥胖和代谢功能障碍.
- 在研究中,WV-OD为极端脂肪饮食提供了一个生理相关的替代方案.
- 在对饮食诱导的肥胖的反应中存在显著的基于性别的差异.
更多相关视频
相关概念视频
Obesity
1.4K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.4K
Regulation of Food Intake
3.0K
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
3.0K
Cholesterol: Significance and Regulation
1.7K
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
1.7K
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
324
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
324
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
250
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
250
Drug Dosing: Obese Patients
315
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
315


