相关实验视频

Updated: Feb 28, 2026

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes
09:12

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes

Published on: December 20, 2019

6.7K

核聚合物抑制RNA的出口,并通过从细胞质聚合物的二次播种形成RNA

Carolyn J Decker, Kathleen McCann, Evan Lester

    bioRxiv : the preprint server for biology
    |February 27, 2026
    PubMed
    概括

    细胞质陶聚合物导致神经退行性疾病如阿尔茨海默氏症的核陶聚合. 这种核积累扰乱了mRNA输出和RNA生物发生,导致tau病理.

    更多相关视频

    An In Vitro Model for Studying Tau Aggregation Using Lentiviral-mediated Transduction of Human Neurons05:51

    An In Vitro Model for Studying Tau Aggregation Using Lentiviral-mediated Transduction of Human Neurons

    Published on: May 23, 2019

    6.5K
    In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein09:22

    In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

    Published on: January 2, 2015

    19.1K

    相关概念视频

    Nuclear Export01:42

    Nuclear Export

    The nucleus restricts several proteins within and allows others to pass. The restricted proteins possess a nuclear retention sequence or NRS, anchoring them to the nuclear lamins and preventing their transport to the cytosol. The non-restricted proteins, after their synthesis, are transported to their site of action, such as the cytosol or other organelles, with the help of nuclear export signals or NES.
    NES are of three types- the canonical 10-residue long leucine-rich signal and other...
    5.1K
    Nuclear Export of mRNA02:31

    Nuclear Export of mRNA

    Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
    8.9K
    Nuclear Export of mRNA02:31

    Nuclear Export of mRNA

    5.5K
    RNA Structure01:19

    RNA Structure

    The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
    Different Types of RNA Have the Same Basic Structure
    There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
    7.9K
    RNA Structure01:23

    RNA Structure

    Overview
    The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
    Different Types of RNA Have the Same Basic Structure
    There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
    79.5K
    Types of RNA01:20

    Types of RNA

    Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
    RNA Performs Diverse...
    10.1K