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Updated: Feb 28, 2026

Using the E1A Minigene Tool to Study mRNA Splicing Changes
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Using the E1A Minigene Tool to Study mRNA Splicing Changes

Published on: April 22, 2021

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基因特异性拼接调节蛋白质异型和阿尔茨海默氏症风险

Alison J King, Kofi Amoah, Laixing Zhang

    bioRxiv : the preprint server for biology
    |February 27, 2026
    PubMed
    概括

    我们在人类大脑中绘制了基因基因特异性的替代拼接 (ASAS),确定了数百个拼接事件和500多个功能性SNP. 这些发现将遗传变异与大脑特征和阿尔茨海默病联系起来,揭示了新的调节机制.

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