胰岛素耐药性改变了对习惯饮食的纵向多基因反应
bioRxiv : the preprint server for biology
|February 27, 2026
概括
饮食对肠道微生物和新陈代谢的影响因胰岛素敏感性而异. 代谢灵活性和特定的肠道细菌调解这些反应,影响心血管疾病风险并告知个性化的营养策略.
科学领域:
- 人类生理学和新陈代谢
- 肠道微生物组研究研究
- 营养科学和心血管健康
背景情况:
- 在各种胰岛素抵抗状态下,习惯性饮食,肠道微生物组和血代谢组之间的相互作用尚未完全理解.
- 个人对饮食的反应可能会有很大差异,影响代谢健康和疾病风险.
研究的目的:
- 研究习惯性饮食如何影响不同程度的胰岛素抵抗个体的肠道微生物组和血代谢组.
- 为了识别饮食-omics协会的微生物和代谢媒介.
- 评估饮食,代谢物和微生物种群对动脉样硬化心血管疾病风险的贡献.
主要方法:
- 在71名成年人中进行了一年多的多omics分析 (饮食,代谢组,肠道微生物组,临床标志物,炎症标志物).
- 黄金标准的胰岛素抑制试验用于评估胰岛素抵抗.
- 机器学习可以推导出饮食模式,并分析由胰岛素敏感性分层的饮食-omics关联.
主要成果:
- 与胰岛素耐药个体相比,胰岛素敏感个体表现出更强的饮食-omics关联,突出了代谢灵活性.
- 肠道细菌Parabacteroides被确定为一种潜在的媒介,将精制碳水化合物摄入量与代谢特征联系起来.
- 饮食,代谢物,微生物种类和免疫标记物独立地对10年动脉样硬化心血管疾病风险预测作出了贡献.
结论:
- 心脏代谢风险的个体间变化部分是由于分子对习惯饮食反应的差异.
- 研究结果支持代谢灵活性和肠道微生物群在调解饮食对健康影响中的作用.
- 结果对精准营养和心血管疾病预防策略有影响.
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