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Updated: Feb 28, 2026

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

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开发和特征小鼠适应的复合SARS-CoV-2表达记者基因的开发和特征

Sara H Mahmoud, Nathaniel Jackson, Ramya S Barre

    bioRxiv : the preprint server for biology
    |February 27, 2026
    PubMed
    概括

    我们开发了一种重组的SARS-CoV-2 (严重急性呼吸系统综合征冠状病毒2),具有用于跟踪小鼠感染的记者基因. 这种新工具允许对病毒传播进行非侵入性监测,并评估野生类型小鼠的治疗方法.

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    Reporter Genes02:11

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    Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
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