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相关概念视频

Nucleic Acid Structure01:25

Nucleic Acid Structure

9.7K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
9.7K
RNA Structure01:23

RNA Structure

79.5K
Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
79.5K
RNA Structure01:19

RNA Structure

7.9K
The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
7.9K
DNA as a Genetic Template02:05

DNA as a Genetic Template

28.2K
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
28.2K
Conserved Binding Sites01:49

Conserved Binding Sites

5.2K
Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
5.2K
Conserved Binding Sites01:49

Conserved Binding Sites

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Analyzing and Building Nucleic Acid Structures with 3DNA
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Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

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亚特拉斯:基于图形的3DRNA动机库,包含非沃森-克里克相互作用.

Jingyi Li, Jian Wang, Srinivasan Ekambaram

    bioRxiv : the preprint server for biology
    |February 27, 2026
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    概括
    此摘要是机器生成的。

    组装和结构高级模板库 (ATLAS) 组织RNA3D结构和图案,包括非沃森-克里克交互. 该资源通过提供图形表示和相似度测量来帮助RNA结构预测和设计.

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    Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
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    科学领域:

    • 结构生物学 结构生物学
    • 生物信息学是一种生物信息学.
    • 计算生物学 计算生物学

    背景情况:

    • RNA 基因是 RNA 功能必不可少的重复性结构模式.
    • 现有的RNA 3D结构库缺乏对非沃森-克里克相互作用和伪结的全面表示.

    研究的目的:

    • 开发用于RNA基因分析的装配和结构高级模板库 (ATLAS).
    • 为RNA3D结构预测和设计提供资源,包括非沃森-克里克相互作用.
    • 根据共享的动机来确定RNA结构相似性的衡量标准.

    主要方法:

    • 开发了RNA结构的图形表示,包括非沃森-克里克相互作用和伪结.
    • 从蛋白质数据库 (PDB) 集成的原子3D结构进入ATLAS.
    • 实现了对象识别的异态图搜索算法.
    • 创建了一个网络服务,用于搜索和下载RNA图案和用户定义的结构.
    • 提出了一种以物理为灵感的RNA进化模型来分析结构相似性.

    主要成果:

    • 亚特拉斯提供RNA基因的核酸水平图形表示和相应的PDB ID.
    • 该库包括3D原子结构,并支持非沃森-克里克相互作用和伪结.
    • 基于共享的动机开发了一种基于RNA相似性的新型测量方法.
    • 拟议的进化模型的稳定状态解决方案与观察到的RNA结构相似性分布保持一致.

    结论:

    • 亚特拉斯是RNA基因分析,预测和设计的综合资源.
    • 包括非沃森-克里克相互作用和伪结增强了RNA结构表示.
    • 开发的相似度测量和进化模型为RNA结构多样性和进化提供了新的见解.