从基质绑定PDB结构定义典型蛋白激酶域的活性构造,使所有437个人类催化蛋白激酶的活性状态AlphaFold2模型成为可能

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Updated: Feb 28, 2026

Modeling an Enzyme Active Site using Molecular Visualization Freeware
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Modeling an Enzyme Active Site using Molecular Visualization Freeware

Published on: December 25, 2021

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Joan Gizzio, Bulat Faezov, Qifang Xu

    bioRxiv : the preprint server for biology
    |February 27, 2026
    PubMed
    概括

    研究人员定义了活性蛋白激酶的结构标准,发现PDB中只有30%处于活性形式. 他们使用AlphaFold2在活跃状态下建模了所有437个人类激酶,为癌症研究提供了宝贵的资源.

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