温度对口味偏好的影响受到TRPM8的影响
bioRxiv : the preprint server for biology
|February 27, 2026
概括
口腔温度显著影响味觉感知. 沉默TRPM8受体会破坏糖味偏好,这表明温度传感和小鼠的味道之间存在联系.
科学领域:
- 神经科学是一个神经科学.
- 感官科学 感官科学
- 味觉感知是一种味觉感知.
背景情况:
- 口腔温度通过调节三角神经元来影响口味感知.
- 三角体热传感和味觉之间的相互作用在很大程度上仍未被探索.
研究的目的:
- 为了研究口腔温度对小鼠口味偏好的影响.
- 确定如何沉默TRPM8 (暂时受体潜力梅拉斯他丁8) 受体会影响这些温度依赖的味道反应.
主要方法:
- 用于TRPM8基因缺陷的雌性和雄性TRPM8基因缺陷和对照小鼠进行了热力测量测试.
- 在冷 (15°C) 和温暖 (30°C) 的温度下,小鼠取样了苦味 (素) 和甜味 (糖/葡萄糖) 的味道溶液.
- 简短访问试验 (10秒) 捕获了行为口腔感官控制.
主要成果:
- 对照和TRPM8缺乏的小鼠对温度变化对苦味的反应都相似.
- 在对照小鼠中,高温 (30°C) 增加了对糖的偏好.
- 在TRPM8缺乏的小鼠中,高温 (30°C) 抑制了糖的偏好,这表明了厌恶反应.
结论:
- 三肢热传感器,特别是通过TRPM8,与甜味偏好相互作用.
- 这些发现表明三角神经神经交叉模式相互作用影响味觉感知.
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