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Updated: Feb 28, 2026

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
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通过设计的生物PROTACs重新编程CAR T细胞.

Vivek S Peche, Sebastian Kenny, Tae Gun Kang

    bioRxiv : the preprint server for biology
    |February 27, 2026
    PubMed
    概括

    新的bioPROTACs提供一种可逆的非基因编辑方法来增强CAR T细胞功能. 这种方法针对T细胞耗尽调节器,为下一代细胞疗法提供可调节的策略.

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    Tumor Immunotherapy01:27

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    Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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