在接受胃肠道癌症初级手术的患者中,针对焦虑和抑郁症进行动态查
Tingting Shi1, Li Gong1, Weili Hang1
1Department of General Surgery, Nanjing First Hospital Nanjing Medical University China.
概括
胃肠道 (GI) 癌症的时间动态查通过减少患者手术后的焦虑和抑郁症,显著改善了1年无疾病生存率. 这种方法还可以增强免疫功能和生活质量.
科学领域:
- 在瘤学瘤学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 焦虑和抑郁是诊断为胃肠道 (GI) 癌症的患者常见和持续的问题.
- 这些心理状况可能会对治疗结果和生活质量产生负面影响.
研究的目的:
- 评估时间动态查方法对焦虑和抑郁的有效性.
- 评估这种查对接受肠胃癌初级手术的患者的影响.
主要方法:
- 分析了876名接受肠道癌症手术的患者队列.
- 一个查队列接受了焦虑和抑郁的动态查,与对照组匹配1:1.
- 主要终点是1年无病生存期 (DFS);次要结局包括炎症标志物,白细胞计数和生活质量评估 (PHQ-9,GAD-7,EQ-5D-5L).
主要成果:
- 查队列的1年DFS (91.4%) 与对照组 (81.2%) 相比显著更高.
- 在查组中,焦虑和抑郁分数 (PHQ-9,GAD-7) 随着时间的推移显著下降.
- 与对照组相比,在查队列中观察到改善的免疫功能标志物 (IL-6,TNF-α,CD3+,CD4+/CD8+比率,NK细胞) 和生活质量 (EQ-5D-5L).
结论:
- 在胃肠道癌患者中,对焦虑和抑郁的时间动态查在手术后是有效的.
- 这种查可以改善心理健康,增强免疫功能,提高生活质量.
- 这种干预措施有助于改善胃肠道癌症患者的1年预后.
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