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Updated: Feb 28, 2026

Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells
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在i神经元中,C9orf72-ALS突变驱动基底线粒功能障碍

James A K Lee1, Chloe Moutin1, Sarah Granger1

  • 1Division of Neuroscience, School of Medicine and Population and Health, Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, United Kingdom.

Frontiers in cellular neuroscience
|February 27, 2026
PubMed
概括

在ALS中发生的运动神经元损失与C9orf72基因突变有关. 患者衍生的神经元显示线粒体功能受损,因自细胞体较少而导致线粒体缩,这表明有毒的功能获取机制.

关键词:
另一种情况是ALS (性侧面硬化症).ULK1 是一个ULK1自自是自的过程.线粒体中的线粒体.线粒细胞衰变 (mitophagy) 是一种神经衰变的过程.

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