目标范围内的24小时缩血压时间与死亡率之间的关联
Lucas Lauder1,2, Igor Schwantke3, Alejandro de la Sierra4
1Department of Cardiology, University Heart Center (L.L., F.M.), University Hospital Basel, Switzerland.
Hypertension (Dallas, Tex. : 1979)
|February 27, 2026
概括
系统性血压 (SBP) 的目标范围 (TTR) 的更高时间与降低的死亡率有关. 这一发现凸显了维持血压在目标范围内的重要性,以获得更好的心血管健康结果.
科学领域:
- 心脏病学 心脏病学
- 高血压管理 高血压管理
- 公共卫生 公共卫生
背景情况:
- 目标范围中的时间 (TTR) 整合了血压 (BP) 的变化和控制.
- 缩血压 (SBP) TTR是 ambulatory BP监测期间血压控制的衡量标准.
- 了解SBP TTR对死亡率的影响对于心血管风险评估至关重要.
研究的目的:
- 调查在门诊血压监测期间SBP TTR与心血管和全因死亡率之间的关联.
- 确定SBP TTR是否是超出平均BP和BP变异性的死亡率的独立预测指标.
主要方法:
- 分析了西班牙门诊血压监测登记处的数据,其中包括48,687名患者.
- 使用连续SBP记录之间的线性插值估计24小时SBP TTR.
- 对人口统计和临床变量进行调整的考克斯回归分析,以评估死亡率关联.
主要成果:
- 较高的24小时SBPTTR与较低的全因死亡率 (HR,0.83每1SD增量) 有显著的关联.
- 更高的24小时SBPTTR也与较低的心血管死亡率有关 (HR,0.80每1SD增量).
- 在对平均24小时SBP和SBP变化进行调整后,这些关联仍然显著.
结论:
- 通过门诊血压监测测量的24小时SBPTTR增加,独立地与减少全因和心血管死亡率有关.
- 门诊血压监测和TTR评估可以为高血压患者提供有价值的预后信息.
- 优化SBP TTR可能是改善高血压患者长期治疗结果的治疗目标.
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