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Updated: Feb 28, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

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一种新型的Nrf2激活剂通过直接干扰Keap1-Nrf2蛋白质-蛋白质相互作用来抑制骨质细胞形成和卵巢切除诱导的骨损失

Shengbin Huang1, Lele Yi2, Yichi Zhang1

  • 1Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China.

Journal of medicinal chemistry
|February 27, 2026
PubMed
概括

这项研究引入了5-烯基-黄化合物5c作为Nrf2信号通路的新型激活剂. 化合物5c有效地抑制骨质细胞形成,为骨质疏松症治疗提供了一个有前途的新疗法策略.

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