英国人格障碍诊断自闭症患者:来自匹配队列研究的证据
Elizabeth O'Nions1, Jude Brown2, Joshua Ej Buckman3,4
1Bradford Teaching Hospitals NHS Foundation Trust, UK.
Autism : the international journal of research and practice
|February 27, 2026
概括
与非自闭症个体相比,自闭症成年人接受人格障碍诊断的可能性要高得多. 这种增加的诊断率,特别是在女性中,在2000年至2019年间上升,需要进一步调查.
科学领域:
- 精神病学是一个精神病学.
- 神经发育障碍 神经发育障碍
- 临床心理学 临床心理学
背景情况:
- 自闭症患者的同时出现人格障碍诊断的比率更高.
- 之前的临床记录和队列研究表明,自闭症人口中性格障碍诊断的可能性不成比例.
研究的目的:
- 调查自闭症成年人与匹配的非自闭症队列相比,人格障碍诊断的发生率.
- 检查自闭症个体随时间推移的人格障碍诊断的趋势,考虑智力障碍状态和性别.
主要方法:
- 一项大型队列研究利用IQVIA医学研究数据库从2000年1月1日到2019年1月16日.
- 包括22,112名自闭症成年人,与1:10匹配的比较组 (n=221,120) 基于年龄,性别和初级保健实践.
- 根据智力障碍状态和性别分层分析,以比较人格障碍诊断率.
主要成果:
- 没有智力障碍的自闭症患者的性格障碍诊断率是对照组的4.6-4.8倍.
- 与对照组相比,智力障碍自闭症患者的发病率是男性的2.0倍,女性的8.3倍.
- 在20岁的自闭症个体中,新的人格障碍诊断率从2009年到2019年增加,女性的明显增加.
结论:
- 人格障碍诊断在自闭症患者中更为普遍,基于智力障碍和性别存在显著差异.
- 从2000年到2019年,在自闭症患者,特别是女性中,人格障碍诊断的趋势越来越大.
- 需要进一步的研究,以了解自闭症人口中人格障碍诊断增加的流行率和趋势的根本原因.
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