牛结核病史作为英格兰牛群复发的风险因素,牛群经历了崩
Daisy Duncan1, Adam Brouwer1, Ricardo de la Rua-Domenech2
1Department of Epidemiological Sciences, WOAH Collaborating Centre in Risk Analysis and Modelling, Animal and Plant Health Agency, Addlestone, UK.
The Veterinary record
|February 27, 2026
概括
牛结核病 (TB) 的复发率在具有病变阳性病变史的群体中更高. 在这些牛群中优先进行干扰素马测试,特别是大型牛群,可以改善结核病管理和控制.
科学领域:
- 兽医流行病学 兽医流行病学
- 动物健康管理 动物健康管理
- 牛病监测 牛病监测 牛病监测
背景情况:
- 牛结核病 (TB) 对英格兰的畜牧业构成重大威胁.
- 干扰素- (IFN-γ) 血液检测可以提高诊断灵敏度,当结核病崩期间补充结核素皮肤检测时.
- 识别患有结核病复发风险较高的群体对于有针对性的测试策略至关重要.
研究的目的:
- 根据最近的结核病病史,确定面临较高牛结核病复发风险的牛群.
- 为改善结核病管理提供针对性部署干扰素马测试的信息.
- 分析过去的结核病状况与未来结核病病例的概率之间的关联.
主要方法:
- 对英国牛群 (2018-2020年) 结核病病例的观察数据的分析.
- 多变量逻辑回归用于评估结核病在病变后18个月内复发的几率.
- 作为一个关键变量,在过去18个月内包括群体结核病状况 (正式退出无结核病 [OTF-W],OTF暂停 [OTF-S],或不存在).
主要成果:
- 具有OTF-W病例史的群体出现复发的几率明显更高 (OR 1.3;95% CI:1.1至1.6).
- 经历过OTF-S病变的病史并没有显著增加复发的风险 (OR 0.9;95% CI:0.8-1.1).
- 大规模的群体被确定为TB复发的另一个重要风险因素.
结论:
- 优先对具有OTF-W病史的牛群进行干扰素马测试,但不一定是具有OTF-S病史的牛群.
- 无论其病史如何,大型群体都可能从有针对性的监测和测试中受益.
- 需要进一步的研究来调查有效的干预措施,防止牛结核病复发.
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