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Updated: Feb 28, 2026

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单原子纳米酶驱动的乳酸逆转燃料氧化代谢和抑制乳酸酶治疗糖尿病伤口

Wei Wu¹, Houqi Zhou¹, Muxin Zhang¹

¹Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing 401147, China.

|February 27, 2026

概括

这项研究引入了一种新型纳米酶,可以有效地将乳酸转化为酸盐,恢复线粒体功能并重编程新陈代谢以对抗慢性炎症. 这一突破为炎症性疾病提供了新的治疗策略.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
免疫学免疫学免疫学

背景情况:

慢性炎症是由活性氧物种 (ROS) 和乳酸积累维持的.
现有的基于金属的纳米酶在有效的乳酸氧化中面临着挑战.
单细胞RNA测序 (scRNA-seq) 识别了炎症微环境中的关键因素.

研究的目的:

开发一种能够有效进行乳酸氧化和ROS清理的纳米酶.
研究电子结构修饰在纳米酶催化活性中的作用.
探索针对炎症中乳酸代谢的治疗潜力.

主要方法:

scRNA-seq分析以确定炎症驱动因素.
开发了一种添加剂的单原子铁纳米酶 (Fe@CN-P).
关于Fe@CN-P电子结构和乳酸氧化催化活性的表征.
评估Fe@CN-P对线粒体活动和代谢途径的影响.

主要成果:

通过增强质子转移,Fe@CN-P有效催化乳酸氧化成酸盐.
兴奋剂调节铁活性中心的电子结构,增加电子密度和质子捕获能力.
纳米酶恢复了线粒体的功能,并建立了代谢过程.
反转-重复使用.
一个路径. 一个路径. 一个路径.
Fe@CN-P 显示了乳酸氧化和ROS清理的双重功能,导致代谢重编程和表观遗传重塑.

结论:

纳米酶的原子级电子结构工程对于提高催化效率至关重要.
Fe@CN-P通过调节细胞代谢来调节炎症,提供了一个有前途的治疗策略.
这项工作为设计具有定制治疗功能的先进单原子纳米酶提供了基础.

关键词:

糖尿病慢性伤口表观遗传调节表观遗传调节乳酸乳酸是一种乳酸.代谢重编程是指代谢重编程.纳米酶纳米酶是一种纳米酶.

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