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内源性密度病毒的进化动态NS1蛋白质揭示了与它们的Platyhelminth宿主古老的密度融合

Han Zhang¹, Juan Xu², Xiaodong Su³

¹Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China.

Microbiology spectrum

|February 27, 2026

概括

平虫中的内源性密度病毒序列揭示了可追溯到6.92亿年前的古代宿主病毒密度融合. 这一发现为重建病毒进化和宿主寄生虫共同进化的历史提供了分子化石.

科学领域:

* 病毒学病毒学
* 进化生物学进化生物学
* 古遗传学是一门古遗传学.

背景情况:

*内源性病毒元素 (EVE) 作为分子化石,对于理解病毒和宿主进化史至关重要.
*EVE为校准病毒进化时间表提供了基准.
*以前的研究还没有在Platyhelminthes中广泛探索密度病毒内源化.

研究的目的:

* 为了研究白金的基因组中densovirus NS1序列的存在和进化动态.
* 通过基因组学和分子分析,重建古代宿主-病毒共聚事件.
* 建立使用内源性病毒元素的古病毒重建框架.

主要方法:

* 横向序列分析,以识别在Platyhelminth基因组中集成的densovirus NS1序列.
* 基因组学分析以确定内源性和外源性病毒序列之间的进化关系.
*结构对齐和距离矩阵分析,以评估蛋白质的保存和分歧.

主要成果:

* 丹索病毒NS1序列在染色体上集成在Platyhelminth基因组中,表明内源化.
*宿主病毒的共同融合可以追溯到埃迪亚卡拉 - 坎布里亚过渡期 (约692 MYA).
*NS1蛋白显示全球分歧,但保留了ATPase和效应子域,表明了适应和功能性保存.
* 对于特定的白金线系的推断分歧时间在190到233 MYA之间.
* 序列分析支持宿主病毒共聚模式,具有跨物种分离和内物种保护.

结论:

* 在Platyhelminthes中,densovirus的内源化提供了古代病毒与宿主共聚的分子证据.
*NS1蛋白中的保存域突出显示了复制关键功能的保存.
* 这项研究提供了一个新的框架,用于使用内源性病毒"分子化石"重建古病毒动态.
*这些发现重塑了对地质时间尺度上的病毒宿主共同进化的理解.

关键词:

金座是宿主中的一个.进化的动态进化的动态主体病毒的密码融合.

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