相关实验视频

Updated: Feb 28, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

丰坦相关性肝病中的肝细胞癌:发病率,风险分层和监测影响

Hideki Onishi¹, Norihisa Toh², Kenji Baba³

¹Department of Gastroenterology and Hepatology, Medical Development Field, Okayama University, Okayama, Japan.

Hepatology communications

|February 27, 2026

概括

患有Fontan相关性肝病 (FALD) 的患者有显著的肝细胞癌 (HCC) 风险. 通过监测及早检测,辅助由高的α-fetoprotein (AFP) 水平,对于可比的生存结果至关重要.

科学领域:

肝病学肝病学是一种肝病学.
在瘤学瘤学.
心脏病学心脏病学

背景情况:

丰坦相关性肝病 (FALD) 是肝细胞癌 (HCC) 的已知危险因素.
有限的数据存在于HCC发病率,风险因素和FALD患者的结果.
这项研究解决了在这个特定人群中更好地理解和管理HCC的需要.

研究的目的:

为了确定FALD患者中HCC的发病率.
确定FALD中HCC发展的独立风险因素.
评估FALD中HCC监测策略的有效性.

主要方法:

120名FALD患者的回顾性队列研究.
在FALD诊断后累计HCC发病率的计算.
多变量分析以确定HCC预测因子和生存分析.

主要成果:

1,2,3年的累计HCC发病率分别为0.9%,2.7%和3.9%.
在FALD诊断时,阿尔法-胎蛋白 (AFP) 的升高是HCC的独立预测因子 (HR 1.29,p=0.01).
在患有或没有HCC的FALD患者之间,整体存活率没有显著差异 (p=0.50).

结论:

患有FALD的患者有不可忽视的HCC风险,这强调了监测的重要性.
在FALD诊断时AFP升高可以帮助针对性HCC监测的风险分层.
常规监测支持FALD患者发展HCC的良好预后,与没有HCC的患者相比.

关键词:

在 FALD 找 FALD 这就是Fontan程序.这是一种α-fetoprotein.这是一项回顾性队列研究.风险分层的分层化

更多相关视频

Laparoscopic Anatomical Resection of the Right Anterior Lobe Based on the Laennec Capsule Technique

Laparoscopic Anatomical Resection of the Right Anterior Lobe Based on the Laennec Capsule Technique

Published on: May 2, 2025

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Published on: April 12, 2024

相关概念视频

Esophageal Varices-II: Clinical Features and Management

Esophageal Varices-II: Clinical Features and Management

Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...