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相关概念视频

Stem Cell Niche01:26

Stem Cell Niche

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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
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The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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相关实验视频

Updated: Feb 28, 2026

3D Organotypic Co-culture Model Supporting Medullary Thymic Epithelial Cell Proliferation, Differentiation and Promiscuous Gene Expression
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性转化细胞产生半同质的,与免疫细胞相互作用.

Sebastian Arcila-Barrera1, Oshri Yosefov-Levi1, Yehuda Shovman2

  • 1The Concern Foundation Laboratories, The Lautenberg Center for Immunology and Cancer Research, Department of Immunology and Cancer Research-IMRIC, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.

Gastroenterology
|February 27, 2026
PubMed
概括

早期的胰腺癌涉及到与免疫细胞相互作用的异质甲基塑性细胞. 这些相互作用创造了一个免疫抑制的微环境,可能导致癌症的进展.

关键词:
亚阴性转化形成症 (Acinar Metaplasia) 是一种转塑性利基 (metaplastic niches) 是指一个转塑性利基.胰腺癌 胰腺癌 胰腺癌

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科学领域:

  • 胰腺癌的研究研究.
  • 细胞代谢细胞代谢.
  • 瘤微环境是一个微环境.

背景情况:

  • 甲基形成是细胞转变的早期阶段,有可能变为恶性.
  • 在胰腺管腺癌中,acinar转化细胞形成前恶性病变.
  • 之前的研究已经确定了7种亚型的甲状腺细胞,但它们的分布和相互作用是未知的.

研究的目的:

  • 为了研究胰腺病变内的甲基塑性细胞亚型的分布和相互作用.
  • 识别与更高度病变相关的超塑性细胞类型及其相互作用.
  • 了解早期胰腺癌中超塑性细胞和肌体/免疫细胞之间的交叉关系.

主要方法:

  • 单细胞RNA测序小鼠和人类样本.
  • 空间转录学用于分析细胞分布和相互作用.
  • 为组织学分析进行血素-素染色.

主要成果:

  • 甲基塑性细胞表现出非随机分布,类似的类型聚集在一起,表明增殖.
  • 特定的细胞类型,如繁殖,衰老,状和首领状细胞,经常发生局部化.
  • 高度病变显示Muc4,Lcn2和Cd274的表达增加,可能导致恶性瘤.
  • 确定了为特定的甲基塑性细胞和相互作用的免疫细胞 (包括中性粒细胞和巨细胞) 丰富的利基.

结论:

  • 甲基塑性细胞可以在癌症发病早期对免疫细胞进行编程.
  • 这种编程支持特定利基内的免疫抑制微环境.
  • 这些发现突出了转质细胞相互作用在早期胰腺癌发展中的作用.